The nerve cells are highly dependent on glucose metabolism. Without glucose metabolism, nerve cells starve and eventually will die. When patients with neuropathy begin the MDI therapy, the nerves throughout the body are immediately fed and begin to respond in a surprising but normal way.

A combination of being able to feel your feet, experiencing increased blood flow and improved health of the tissues will reduce the chance of blisters developing again and heal those that are already in place. This could mean preventing amputations

Kidney Disease

Patients with chronic kidney disease (CKD) experience a loss of creatinine clearance (CrCl) of 8-10 “points” per year (units are mL/min) even when they are tightly controlling their blood sugar. With MDI, this filtration related number has been proven to improve dramatically. This means that patients with 1/3 of their kidney function (CrCl > 30 – 40) should never progress to dialysis, and those with higher function will actually increase their filtration levels. Also, protein in the urine will be reduced. Patients with CrCl > 50 – 60 have seen their kidneys actually improve their functioning level.

Individuals with diabetes in CKD Stage 3 and 4 should never advance to Stage 5 (End Stage Renal Disease) and dialysis. Those in Stage 3A will most likely begin to improve their kidney function.

Erectile Dysfunction

Patients with sexual dysfunction (both male and female) can expect to regain that function, as feeling and increased blood flow returns to all of the extremities. ED can be reversed if the patient was able to achieve an erection within the last 5 to 10 years.

Hypoglycemic Episodes

Hypoglycemic awareness is restored and reduced by 98%.


Dramatic improvement in hypertension in just 90 days. Amounts of medications necessary to maintain acceptable blood pressure levels will be reduced or eliminated.


The cells in the eyes are particularly sensitive to glucose metabolism. Most patients who were experiencing vision problems due to their diabetes report improved vision after just a few MDI sessions. This includes color recognition and brightness.

Patients with diabetic retinopathy can expect to avoid further laser treatment. Depending on the severity of their current condition, they should expect improving eye health and significant vision improvement.

Gastrointestinal Fatigue

When GI problems are caused by diabetes, patients have seen relief as a result of MDI therapy. Gastroparesis is a form of neuropathy, so patients have seen rapid relief from this complication of the disease.


Patients’ wounds heal, even if these wounds have not closed for many years. Diabetes is the number-one cause of non-traumatic amputations worldwide. These amputations should be avoided for any patients on MDI therapy as most all of the wounds are expected to heal. With increased blood flow, future wounds can be avoided as the skin gets healthier. Feeling returns to the extremities, allowing an awareness if a blister is developing.

Chronic Fatigue and Muscle Fatigue

Effectively treated by the therapy, patients will see dramatic energy level improvement, particularly where energy levels have become a problem.

Heart Disease

The heart muscle responds very well to the MDI therapy and increased carbohydrate metabolism. The heart especially enjoys carbohydrate metabolism because there is no need for the extra oxygen required for lipid and free fatty acid metabolism. That is why diabetes heart disease (cardiomyopathy) is a major problem which does not respond well to tight glucose control. (In fact, tight glucose control worsens diabetic heart disease and has been reported to cause more frequent heart attacks). MDI patients with low ejection fractions can expect to improve dramatically and return to significantly higher ejection fractions and higher energy levels. This reduces the chances of congestive heart failure which is the cause of many diabetic deaths.